Methyl malonyl chloride

Clear light yellow to yellow liquid

Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs.

Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates.

Methylmalonyl chloride can be obtained by reacting hydrogen methylmalonate with oxalyl chloride. Take out the 100 mL clean flask from the oven and cool it to room temperature under argon, add 5 mL of methylene chloride and 1.0 g (8.5 mmol) of hydrogen methylmalonate to the reaction flask and add a drop of DMF during stirring, add 1.2 g (9.4 mmol) of oxalyl chloride to the reaction flask slowly in an ice bath for 5 minutes, withdraw the ice bath, and react for 2 hours at room temperature, then evaporate and concentrate the mixture to obtain methylmalonyl chloride with a rotary evaporator. The reaction was carried out for 2 hours at room temperature and concentrated by rotary evaporator to obtain methyl malonate chloride.