甘珀酸钠
甘珀酸钠 性质
| 熔点 | >275°C (dec.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa1 4.18; pKa2 5.52(at 25℃) |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water to 100 mM. |
| 稳定性 | 吸湿性 |
| LogP | 7.083 (est) |
| CAS 数据库 | 7421-40-1(CAS DataBase Reference) |
甘珀酸钠 用途与合成方法
IC50: human 11β-HSD; bacterial 3α, 20β-HSD; gap junction; Vaccinia virus
Carbenoxolone disodium (6-150 μM; pre-treatment 1 hour) inhibits Vaccinia virus (VACV) replication in a gap junction-independent in HaCaT cells, and it has toxicity effects on VACV-A5L-EGFP infected cells at 48 h.Carbenoxolone (30 μM; pre-treatment 1 hour) does not upregulate PP2A expression, but induces the late protein A27 expression in hacat cells.
Cell Viability Assay
| Cell Line: | HaCaT cells |
| Concentration: | 6 μM, 12 μM, 30 μM, 60 μM, 150 μM |
| Incubation Time: | Pre-treatment 1 hour |
| Result: | Had no toxicity until 48 hours at high dose in virus-infected cells. |
Western Blot Analysis
| Cell Line: | HaCaT cells |
| Concentration: | 30 μM |
| Incubation Time: | Pre-treatment 1 hour |
| Result: | Presented an obvious upregulation of A27. |
Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Diazepam) does not induce a muscle relaxant activity and shows muscle relaxant activity compared to normal saline, and this effect was more than diazepam in the traction test.Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Pentylenetetrazole) significantly increases sleeping time and decreases latency in mice as a dose-dependent manner in Pentylenetetrazole (PTZ) Seizure model. The ED 50 value is 83.3 mg/kg (%95 CL:556.29).
| Animal Model: | Male BALB/c mice |
| Dosage: | 100, 200 and 300 mg/kg |
| Administration: | Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole |
| Result: | Significantly increased the sleeping time in mice. |
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 22-36 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| RTECS号 | RK0250000 |
| 毒性 | LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan) |
