基本属性 稳定性和贮藏条件管理情况功能安全唯一成分标识配伍禁忌来源 用途与合成方法 供应商 供应信息
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麝香草酚(药用辅料)

基本属性 稳定性和贮藏条件管理情况功能安全唯一成分标识配伍禁忌来源 用途与合成方法 供应商 供应信息
麝香草酚(药用辅料)
麝香草酚(药用辅料) 用途与合成方法
  • 稳定性和贮藏条件麝香草酚应该置于密封、避光容器,在阴凉、干燥的地方保存。遇光分解[1]。 [1]R.C.罗,P.J.舍斯基,P.J.韦勒.药用辅料手册[M].北京:化学工业出版社,2005.
  • 管理情况GRAS listed. Included in the FDA Inactive Ingredients Guide (inhalation, liquid; oral, powder for solution). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. [1][1] R.C.罗,P.J.舍斯基,P.J.韦勒.药用辅料手册[M].北京:化学工业出版社,2005.
  • 功能Thymol is a phenolic antiseptic, which has antibacterial and antifungal activity. However, it is not suitable for use as a preservative in pharmaceutical formulations because of its low aqueous solubility. The antimicrobial activity of thymol against eight oral bacteria has been studied in vitro. Inhibitory activity was noted against almost all organisms, and a synergistic effect was observed for combinations of thymol and eugenol and of thymol and carvacrol.The activity of thymol against bacteria commonly involved in upper respiratory tract infections has also been shown. Thymol is a more powerful disinfectant than phenol, but its low water solubility, its irritancy to tissues, and its inactivation by organic material, such as proteins, limit its use as a disinfectant. Thymol is chiefly used as a deodorant in antiseptic mouthwashes, gargles, and toothpastes, such as in Compound Thymol Glycerin BP, in which it has no antiseptic action. Thymol is also a true antioxidant and has been used at concentrations of 0.01% as an antioxidant for halothane, trichloroethylene, and tetrachloroethylene. More recently, thymol has been shown to enhance the in vitro percutaneous absorption of a number of drugs, including 5-fluorouracil, piroxicam, propranolol, naproxen, and tamoxifen. Studies have also demonstrated that the melting point of lidocaine is significantly lowered when it is mixed with thymol. The inhalation of thymol, in combination with other volatile substances, is used to alleviate the symptoms of colds, coughs, and associated respiratory disorders. Externally, thymol has been used in dusting powders for the treatment of fungal skin infections. Thymol was formerly used in the treatment of hookworm infections but has now been superseded by less toxic substances. In dentistry, thymol has been mixed with phenol and camphor to prepare cavities before filling, and mixed with zinc oxide to form a protective cap for dentine.Thymol has been included in food, perfume, and cosmetic products, and has also been used as a pesticide and fungicide.
  • 安全Thymol is used in cosmetics, foods, and pharmaceutical applications as an excipient. However, thymol may be irritating when inhaled or following contact with the skin or eyes. It may also cause abdominal pain and vomiting, and sometimes stimulation followed by depression of the central nervous system following oral consumption. Respiratory arrest, attributed to acute nasal congestion and edema, has been reported in a 3-week-old patient due to the erroneous intranasal application of Karvol, a combination product that includes thymol. The patient recovered, but it was recommended that inhalation decongestants should not be used in children under the age of 5 years.(10) LD50 (guinea pig, oral): 0.88 g/kg(11) LD50 (mouse, IP): 0.11 g/kg LD50 (mouse, IV): 0.1 g/kg LD50 (mouse, oral): 0.64 g/kg LD50 (mouse, SC): 0.243 g/kg LD50 (rat, oral): 0.98 g/kg[1] R.C.罗,P.J.舍斯基,P.J.韦勒.药用辅料手册[M].北京:化学工业出版社,2005.
  • 唯一成分标识3J50XA376E
  • 配伍禁忌Thymol is incompatible with iodine, alkalis, and oxidizing agents. It liquefies, or forms soft masses, on trituration with acetanilide, antipyrine, camphor, monobromated camphor, chloral hydrate, menthol, phenol, or quinine sulfate. [1][1] R.C.罗,P.J.舍斯基,P.J.韦勒.药用辅料手册[M].北京:化学工业出版社,2005.
  • 来源Thymol is obtained from the volatile oil of thyme (Thymus vulgaris Linne (Fam Labiatae)) by fractional distillation followed by extraction and recrystallization. Thyme oil yields about 20–30% thymol. Thymol may also be produced synthetically from p-cymene, menthone, or piperitone, or by the interaction of m-cresol with isopropyl chloride. [1][1] R.C.罗,P.J.舍斯基,P.J.韦勒.药用辅料手册[M].北京:化学工业出版社,2005.
麝香草酚(药用辅料)供应商更多
  • 公司名称:成都华邑药用辅料制造有限责任公司
  • 联系电话:028-86158030
  • 产品介绍: 中文名称:麝香草酚(药用辅料)
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  • 公司名称:江西阿尔法高科药业有限公司
  • 联系电话:18936077580
  • 产品介绍: 中文名称:麝香草酚(药用辅料)
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