Chlorphoxim is an organophosphate insecticide. Little information is available regading its environmental fate It is highly toxic to birds but has a low fish toxicity. Mammalian toxicity is also considered to be low but chlorphoxim is a cholinesterase inhibitor and a neurotoxin.
Pure product is white crystal. m.p. 65～66℃, vapor pressure less than 7.99×10-3Pa. 20℃, solubility in cyclohexanone and toluene is 40%～60%, solubility in water is 1.7mg/L. The product has been used in the manufacture of the product.
Chlorphoxim is an organophosphate insecticide.
Chlorphoxim is commercially synthesised by esterifying O,O-diethyl phosphorothioic acid with an oxime derivative of o-chlorophenylglyoxylonitrile. More specifically, the production process begins with the preparation of o-chlorophenylglyoxylonitrile, which is converted into its oxime form. This intermediate is then reacted with O,O-diethyl phosphorothioic acid chloride under controlled conditions to form the active ester. The reaction typically occurs in an organic solvent with a base to neutralize the by-products and ensure high yield.
Acetylcholinesterase (AchE) inhibitor - after conversion to the oxygen analogue
