Perfluorotripropylamine

Perfluorotripropylamine is a reagent used in the surface modification of droplet polymeric microfluidic devices. This is used to improve the stable and continueous generation of aqueous droplets.

ChEBI: Perfluorotripropylamine is an organofluorine compound. It has a role as a blood substitute. It is functionally related to a tripropylamine.

The half-life of perfluorotripropylamine is 65 days, with excellent emulsification properties[1]. This perfluorocarbon chemical is also used in the following field：
Used as corrosion inhibitor, transmission fluid, and dielectric insulating oil for instruments.
Used as leakage detection liquid of electronic components and devices.
Used as antioxidant lubricant
Used as a cleaning agent for electronics, CD-ROM, and precision instruments.

Perfluorotripropylamine (PFTA, FTPA or FC-3283), with the chemical formula N(CF₂–CF₂–CF₃)₃, is a fluorinated amine compound. In the medical field, it is used as a plasma volume expander, i.e. an oxygen-carrying agent (blood substitute) used as a red blood cell substitute [2]. In a medical model, it was encapsulated within a copolymer as a perfluorocarbon oxygen carrier; a PLGA-PEG/FC-3283 emulsion was prepared using poly(lactic-co-glycolic acid) (PLGA) modified with polyethylene glycol (PEG) for the purpose of highly efficient cellular reoxygenation. HCT 116 cells subjected to hypoxia treatment showed a significant increase in viability following treatment with this emulsion [3].

Purify it as for perfluorodimethyl-cyclopropane (see p 220). [Haszeldine J Chem Soc 102 1951, for azeotropes see Simons & Linevsky J Am Chem Soc 74 4750 1972.] IRRITANT.

[1] Cohn, S M. “Blood substitutes in surgery.” Surgery 127 6 (2000): 599–602.
[2] Manteau, B., Pazenok, S., Vors, J.-P., Leroux, F. R. (2010). New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines. Journal of Fluorine Chemistry, 131(2), 140–158. https://doi.org/10.1016/j.jfluchem.2009.09.009
[3] Wen, Z., Wen, Z., Liu, R., Yi, F., Yao, Y., Guan, J., He, D., Zhu, J., Lin, Z., Liu, R., Yi, F., Yao, Y., Guan, J., He, D., Zhu, J., Lin, Z. (2016). Preparation of Perfluorocarbon Emul-sion and Its Application in Cells Re-oxygenation. General Chemistry, 2(1), 38–43. https://doi.org/10.21127/yaoyigc.20150019