(-)-Ketoconazole along with other Ketoconazle stereoisomers can be used in pharmacological activity and biological study for inducing CYP4501A1 in human and mouse hepatoma. (-)-Ketoconazole has adverse effect as impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor.
ChEBI: (2S,4R)-ketoconazole is a cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration. It is an enantiomer of a (2R,4S)-ketoconazole.
