Nonanoyl chloride is used for the acylation of amine groups of chitosan to simultaneously improve its material properties and adsorption capacity. It was also used in the synthesis of N-nonanoyl piperonylamide, caged vanilloid, N-(4-hydroxy-3-methoxybenzyl)-N-(2-nitrobenzyl)-nonanoylamide or N-(2-Nitrobenzyl)-N-vanillyl-nonanoylamide, n-benzylnonanamide.
Reflux it with acetyl chloride (~ 3 volumes) for 1hour, then distil off AcCl followed by the nonanoyl chloride at ~12mm. It is moisture sensitive and should be stored in sealed ampoules. [Beilstein 2 IV 1023.]
