3-Amino-5-bromopyridine-2-carboxamide

412035-35-9

669066-89-1

(4) Preparation of 3-amino-5-bromopyridine-2-carboxamide: 5-bromo-3-nitropyridine-2-carboxamide (400 mg, 1.63 mmol), ammonium chloride (435 mg, 8.15 mmol), and iron powder (273 mg, 4.89 mmol) were suspended in a solvent mixture of methanol (6 mL) and water (3 mL), and the reaction was stirred at 100°C for for 20 hours. After completion of the reaction, it was cooled to room temperature, filtered through diatomaceous earth and the diatomaceous earth was washed with methanol. The filtrates were combined and concentrated under reduced pressure. The residue was dissolved in chloroform and the organic layer was washed with water. The organic layer was separated and concentrated under reduced pressure to afford the target compound 3-amino-5-bromopyridine-2-carboxamide (246 mg, 70% yield).