Sulfasuxidine,MSD,US,1942
Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
Succinylsulfathiazole is antibacterial
ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.
3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2-
sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for
five minutes after the addition was complete at which time all of the solids
were in solution. The solution was then cooled and diluted with an equal
volume of water. The white solid precipitate which formed was filtered and
recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole,
melting at 184°C to 186°C.
Antibacterial (intestinal)
