Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
https://pubchem.ncbi.nlm.nih.gov/compound/Dexpanthenol#section=Top
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clear colorless to slightly yellow viscous liquid
Bepanthene,Roche,France,1951
immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic
Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.
D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.
ChEBI: Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.
130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid
lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by
weight of 3-hydroxypropylamine are added, in one portion, to the solution and
the mixture is well stirred. While the reaction sets in, the temperature of the
mixture gradually rises by itself to about 50°C and then drops again after
about two hours. To cause completion of the reaction, the mixture is allowed
to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from
methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It
boils under a pressure of 0.02 mm between 118° and 120°C.
D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).
Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flammability and Explosibility
Non flammable
D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.
Pan(to)thenol is the alcohol corresponding to pantothenic
acid, of the vitamin B5 group. It is used as a food additive,
and in skin and hair products as a conditioning agent.
Contact dermatitis and urticaria have been reported.
Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.
Veterinary Drugs and Treatments
Dexpanthenol has been suggested for use in intestinal atony or distension,
postoperative
retention of flatus and feces, prophylaxis and
treatment of paralytic ileus after abdominal surgery or traumatic
injuries, equine colic (not due to mechanical obstruction) and any
other condition
when there is an impairment of smooth muscle
function. Controlled studies are lacking with regard
to proving the
efficacy of the drug for any of these indications.
Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]
