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D-PANTOTHENIC ACID

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D-PANTOTHENIC ACID Basic information
D-PANTOTHENIC ACID Chemical Properties
  • Melting point:178-179℃
  • alpha D25 +37.5°
  • Boiling point:360.05°C (rough estimate)
  • Density 1.266
  • refractive index 1.4315 (estimate)
  • pka4.30±0.10(Predicted)
  • EPA Substance Registry SystemD-Pantothenic acid (79-83-4)
Safety Information
  • ToxicityLD50 intraperitoneal in mouse: 1443mg/kg
D-PANTOTHENIC ACID Usage And Synthesis
  • OriginatorPanto-250 , Bio-Tech Pharmacal
  • UsesLabelled Pantothenic Acid
  • UsesVitamin B5 is water-soluble. It is required for proper growth and maintenance of the body and is involved in body processes such as energy release from carbohydrates and metabolism of fatty acids. It is relatively stable through storage and is found in liver, eggs, and meat.
  • Manufacturing ProcessIsobutylaldehyde reacted with formaldehyde in the presence potassium chromate as a result 2,2-dimethyl-3-hydroxy-propanal was obtained.
    The 2,2-dimethyl-3-hydroxy-propanal was treated by sodium cyanide so 2,4dihydroxy-3,3-dimethyl-butironitrile was prepared.
    The 2,4-dihydroxy-3,3-dimethyl-butironitrile was treated hydrochloric acid and D,L-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one (D,L-pantolacton) was obtained. The racemic mixture of D- and L-pantolactons was a division of Dand L- isomers by the adding of α-phenylethylamine. So D-pantolacton was isolated.
    Acrylic acid contacted with NH3and β-alanine was obtained.
    D-Pantalacton reacted with β-alanine as a result 3-(2,4-dihydroxy-3,3dimethyl-butyrylamino)-propanoic acid was produced
  • brand nameCalpan (BASF); Pantholin (Lilly).
  • Therapeutic FunctionVitamin
  • Safety ProfileModerately toxic by subcutaneous and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx.
D-PANTOTHENIC ACID Preparation Products And Raw materials
D-PANTOTHENIC ACID(79-83-4)Related Product Information
D-PANTOTHENIC ACIDSupplierMore
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  • Tel:18981987031 400-1166-196
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