A complex alkaloid, thaliblastine occurs in Thalictrum minus elatum and has
been assigned the structure given on the basis of chemical and spectroscopic
investigations. The alkaloid has marked antitumour activity but rapid administration of the base causes brachycardia, hypotension and inhibition of
respiration in laboratory animals. Slow intravenous injection, however,
produces none of these effects. Thaliblastine is cytotoxic to HEF and Sa9
cells in vitro.
ChEBI: Thalicarpine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Todorov, Damyanova,Dokl. Bolg. Akad. Nauk., 28, 709 (1975)
