S-Bioallethrin is a yellow liquid. It is miscible with most organic solvents. S-Bioallethrin is the ester of the (1R, trans)-acid with (1S)-allethrolone. S-bioallethrin is a synthetic pyrethroid with fast knock-down activity against household pest insects. It is several times as effective as allethrin against flying and crawling insects. It is used in public health applications against mosquitoes, houseflies and cockroaches.
S-Bioallethrin, by far the most potent constituent of allethrin, is a contact insecticide with rapid knockdown effect. Its effectiveness is enhanced by the addition of a synergist such as piperonyl butoxide or MGK 264 in pesticide formulations. It is used in aerosols, coils or sprays indoors against flying and crawling insects.
ChEBI: (+)-trans-(S)-allethrin is a (+)-trans-allethrin. It is an enantiomer of a (-)-trans-(R)-allethrin.
S-bioallethrin is produced by adapting the standard allethrin manufacturing route to deliver the biologically active S-enantiomer with high optical purity. Commercial processes begin with assembly of the chrysanthemic acid moiety from cyclopropane based precursors, followed by preparation of the allethrolone alcohol fragment through controlled allylic oxidation and rearrangement chemistry. The two components are then coupled via esterification, but with an added stereochemical control step: manufacturers either use enantioselective synthesis of the chrysanthemate portion or resolve a racemic intermediate to isolate the S-configured acid before ester formation. Final purification yields a stable technical grade ester suitable for formulation.
Clear to amber viscous liquid. A synthetic insecticide structurally similar to pyrethrin.
ALLETHRIN is incompatible with alkalis.
Non-systemic, contact and stomach action with a rapid knock-down effect. Sodium channel modulator.
