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Tioxolone

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Tioxolone Basic information
Tioxolone Chemical Properties
  • Melting point:158-160 °C(lit.)
  • Boiling point:267.1°C (rough estimate)
  • Density 1.4844 (rough estimate)
  • refractive index 1.5151 (estimate)
  • storage temp. Inert atmosphere,Room Temperature
  • solubility 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
  • pka8.14±0.20(Predicted)
  • Merck 9456
  • CAS DataBase Reference4991-65-5(CAS DataBase Reference)
  • NIST Chemistry ReferenceTioxolone(4991-65-5)
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-36/37/38
  • Safety Statements 26
  • WGK Germany 3
  • RTECS DM2953750
MSDS
Tioxolone Usage And Synthesis
  • Chemical Propertieslight yellow to beige powder
  • OriginatorAcnosan,Unia
  • Usesantiseborrhoic
  • DefinitionChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.
  • Manufacturing Process40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids.
    A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.
  • Therapeutic FunctionAntiseborreic, Antifungal, Keratolytic
Tioxolone(4991-65-5)Related Product Information
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