依诺昔酮
依诺昔酮 性质
| 熔点 | 255-258°C |
|---|---|
| 密度 | 1.33 |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO：28 mg/mL，可溶 |
| 酸度系数(pKa) | 10.37±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄色 |
| InChI | 1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) |
| InChIKey | ZJKNESGOIKRXQY-UHFFFAOYSA-N |
| SMILES | CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2 |
| CAS 数据库 | 77671-31-9(CAS DataBase Reference) |
依诺昔酮 用途与合成方法
|
PDE3/PDE Ⅲ 5.9 μM (IC 50 ) |
PDE4A 21.1 μM (IC 50 , myocardial PDE4A) |
In vitro, 10 μM Enoximone-treated bronchoalveolar lavage (BAL) eosinophils induced by IL-33 treatment shows significantly lower CD11b expression when compared with diluent-treated BAL eosinophils.
Topical Enoximone (25 μg; intratracheal route) abrogates house dust mite (HDM)-induced allergic airway inflammation.
The Enoximone-treated (25 μg; for 5 days) HDM-exposed mice shows significant reductions in inflammatory cell numbers including eosinophils, macrophages, neutrophils, ILC2s, and T cells, indicating that Enoximone treatment reduces airway inflammation.
依诺昔酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-B1639 | 依诺昔酮 | 77671-31-9 | 1 mg | 434 |
| 2026-06-05 | HY-B1639 | 依诺昔酮 | 77671-31-9 | 5 mg | 1000 |
