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Lynestrenol

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Lynestrenol Basic information
Lynestrenol Chemical Properties
  • Melting point:158°C
  • alpha D -13° (chloroform)
  • Boiling point:366.92°C (rough estimate)
  • Density 1.0083 (rough estimate)
  • refractive index 1.4500 (estimate)
  • solubility Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).
  • pka13.12±0.40(Predicted)
  • form neat
  • color Crystals from MeOH
  • Merck 14,5629
  • CAS DataBase Reference52-76-6
  • EPA Substance Registry SystemLynestrenol (52-76-6)
Safety Information
  • RTECS RC8964300
  • HS Code 2937230000
Lynestrenol Usage And Synthesis
  • Chemical PropertiesWhite or almost white, crystalline powder.
  • UsesProgestogen;Antioestrogen
  • brand nameAnacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.
  • World Health Organization (WHO)Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
  • Safety ProfileAn experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge
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