N-辛酰基-D-神经鞘氨醇
N-辛酰基-D-神经鞘氨醇 性质
| 熔点 | 68-70°C |
|---|---|
| 沸点 | 541.37°C (rough estimate) |
| 密度 | 0.9974 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | −20°C |
| 溶解度 | 可溶于DMSO或乙醇：可溶 |
| 形态 | 蜡状固体 |
| 颜色 | 白色 |
| 稳定性 | 对温度敏感 |
| CAS 数据库 | 74713-59-0(CAS DataBase Reference) |
N-辛酰基-D-神经鞘氨醇 用途与合成方法
|
PKC
|
apoptosis
|
autophagy
|
C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.
Cell Viability Assay
| Cell Line: | CALO cells, INBL cells, HeLa cells |
| Concentration: | 3 μM |
| Incubation Time: | 48 hours |
| Result: | Markedly reduced the tumor cell number. |
Cell Proliferation Assay
| Cell Line: | H1299 cells |
| Concentration: | 10 µM, 20 µM, 30 µM, 40 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC 50 of 22.9 µM. |
Cell Cycle Analysis
| Cell Line: | H1299 cells |
| Concentration: | 10 µM, 20 µM, 30 µM, 40 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Caused the G1 arrest. |
Apoptosis Analysis
| Cell Line: | H1299 cells |
| Concentration: | 10 µM, 20 µM, 30 µM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Increased the level of cleaved caspase-3. |
C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8
+
and CD4
+
T cell responses to viral infections in virus infected mice.
| Animal Model: | C57BL/6 mice, with lymphocytic choriomeningitis virus infected |
| Dosage: | 0.1 mg/kg |
| Administration: | Intranasal administration |
| Result: | Increased the CD8 + T cell response to influenza in the lungs. |
N-辛酰基-D-神经鞘氨醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-108391 | N-辛酰基-D-神经鞘氨醇 | 74713-59-0 | 5mg | 950 |
| 2024-11-08 | HY-108391 | N-辛酰基-D-神经鞘氨醇 | 10 mg | 1650 |
