D-鞘氨醇
D-鞘氨醇 性质
| 熔点 | 74.2-78.1 °C |
|---|---|
| 沸点 | 440.8°C (rough estimate) |
| 密度 | 0.9758 (rough estimate) |
| 折射率 | 1.5000 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | 氯仿：20 mg/mL，澄清，无色至微黄色 |
| 酸度系数(pKa) | 11.80±0.45(Predicted) |
| 形态 | 粉末或蜡状固体 |
| 颜色 | 白色至奶油色 |
| Merck | 14,8747 |
| BRN | 1727294 |
| 稳定性 | 稳定的。与强酸、强碱、强氧化剂不相容。 |
| InChIKey | WWUZIQQURGPMPG-KRWOKUGFSA-N |
| CAS 数据库 | 123-78-4 |
D-鞘氨醇 用途与合成方法
|
p32 8 μM (EC 50 ) |
PKC
|
PP2A
|
Human Endogenous Metabolite
|
A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.
