N,O-Dimethylhydroxylamine hydrochloride

N,O-Dimethylhydroxylamine hydrochloride is white to off-white crystals or crystalline powder

N,O-Dimethylhydroxylamine hydrochloride is used for preparation of an inhibitor of the NLS-derived BC peptides.

Reagent for the preparation of Weinreb amides recently used in the synthesis of 2-acyloxazoles from 2-oxazolemagnesium chloride.

N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.

N,O-Dimethylhydroxylamine hydrochloride was synthesised by methylation, saponification and decarboxylation reactions using chloroformate ester (I) as the starting material. The specific reaction procedure is as follows: First, hydroxylamine hydrochloride is used to treat chloroformate (I). The resulting N-ethoxycarbonylhydroxylamine (II) is then subjected to methylation. Compound (III) undergoes saponification and decarboxylation to yield N,O-Dimethylhydroxylamine hydrochloride (IV).