ML 204

Product NameML 204
CAS2070015-10-8
MFC15H19ClN2
MW262.78
EINECS
MOL File2070015-10-8.mol

Chemical Properties

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Solid
color	White to off-white

Usage And Synthesis

Biological Activity

ML204 is a potent and selective inhibitor of TRPC4/TRPC5 channels with 20-fold selectivity over TRPC6, without affecting other TRP channels and voltage-gated sodium, potassium or Ca2+ channels.

in vitro

ML204 inhibits TRPC4β-mediated intracellular Ca ²⁺ rise with an IC ₅₀ value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
It blocks TRPC4β activity induced through either G _i/o stimulation by μ-opioid, 5HT _1A serotonin, and M ₂ muscarinic receptors or G _q/11 stimulation by the endogenous M ₃ -like muscarinic receptors.
It blocks LPS-induced TRPC5 channel activity.

in vivo

ML204 (1 mg/kg; sc; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.

< td class="col2"> Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) < td class="col2"> Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.

Animal Model:	Nonfasted male C57BL/6 (2-3 months)
Dosage:	1 mg/kg
Administration:
Result:

target

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TRPC4

TRPC5