N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

Product NameN-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
CAS381168-77-0
MFC19H12F2N4
MW334.32
EINECS
MOL File381168-77-0.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	DMSO: ≥ 125 mg/mL (373.89 mM)
form	Solid
color	Light yellow to yellow

Usage And Synthesis

Biological Activity

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.

in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.

target