ML 204
- Product NameML 204
- CAS2070015-10-8
- CBNumberCB23373068
- MFC15H19ClN2
- MW262.78
- MDL NumberMFCD30377212
- MOL File2070015-10-8.mol
Chemical Properties
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
ML 204 Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-5790 | 5mg | $50 | ML204(hydrochloride) 99.64% |
Buy |
| ChemScene CS-5790 | 10mg | $80 | ML204(hydrochloride) 99.64% |
Buy |
| AK Scientific 3084DH | 5mg | $109 | ML204hydrochloride |
Buy |
| ChemScene CS-5790 | 50mg | $180 | ML204(hydrochloride) 99.64% |
Buy |
| ChemScene CS-5790 | 100mg | $280 | ML204(hydrochloride) 99.64% |
Buy |
ML 204 Chemical Properties,Usage,Production
Biological Activity
ML204 is a potent and selective inhibitor of TRPC4/TRPC5 channels with 20-fold selectivity over TRPC6, without affecting other TRP channels and voltage-gated sodium, potassium or Ca2+ channels.in vitro
ML204 inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
It blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors.
It blocks LPS-induced TRPC5 channel activity.
in vivo
ML204 (1 mg/kg; sc; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.
| Animal Model: | Nonfasted male C57BL/6 (2-3 months) |
| Dosage: | 1 mg/kg |
| Administration: | < td class="col2"> Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)|
| Result: | < td class="col2"> Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
target
| TRPC4
| TRPC5
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 | |
| +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 | |
| +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 | |
| QQ:65489617 15618227136 |
info@SuperLan-chem.com | China | 9445 | 58 | |
| 010-50973130 4009686088 |
3193328036@qq.com | China | 29797 | 68 | |
| 0519-85788828 13775037613 |
sales@chemrenpharm.com | China | 3553 | 58 | |
| 88888888888 | hongquchem@qq.com | China | 5132 | 58 | |
| 18964309092 18964309092 |
2769493375@qq.com | China | 2635 | 58 | |
| 010-60605840 15801484223 |
psaitong@jm-bio.com | China | 29834 | 58 | |
| 18818260767 | sales@chemegen.com | China | 6975 | 58 |
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