毛蕊花糖苷
毛蕊花糖苷 性质
| 熔点 | 232℃ |
|---|---|
| 沸点 | 908.8±65.0 °C(Predicted) |
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO（微溶）、乙酸乙酯（微溶）、甲醇（微溶） |
| 酸度系数(pKa) | 9.31±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
| 稳定性 | 吸湿性 |
| 主要应用 | 代谢组学 维生素、营养保健品和天然产品 |
| 化妆品成分功效 | 螯合剂 皮肤保护 抗氧化剂 美白 |
| InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N |
| SMILES | O([C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O)C)[C@@H]1[C@H]([C@@H](O[C@@H]([C@H]1OC(=O)/C=C/C1C=CC(=C(C=1)O)O)CO)OCCC1C=CC(=C(C=1)O)O)O |
| LogP | 0.077 (est) |
| CAS 数据库 | 61276-17-3(CAS DataBase Reference) |
毛蕊花糖苷 用途与合成方法
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PKC 25 μM (IC 50 ) |
Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 µM. Verbascoside shows K i s of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells.
Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3.
药理药效:具有调节免疫、抗氧化、增强体力、抗疲劳、等药理作用。
毛蕊花糖苷 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-N0021R | 毛蕊花糖苷 | 61276-17-3 | 5 mg | 900 |
| 2026-09-15 | HY-N0021R | 毛蕊花糖苷 | 61276-17-3 | 10 mg | 1445 |
