2-(2-Dicyclohexylphosphanyl-phenyl)-1-Methyl-1H-indole

1. Suzuki-Miyaura Coupling of Aryl Mesylates and alkenyl tosylate and mesylate bearing alkyl, methoxy, aldehyde, keto, nitrile, ester, and heteroaryl substitution.
2. Sonogashira Coupling of Aryl Mesylates, R' = alkyl, aryl; R = C(O)R, COOMe, CHO, CN.
3. Buchwald-Hartwig Amination of Aryl Mesylates, R = cyano, chloro, methoxy, keto, ester and etc.
4. Additional catalyzed reactions include Cyanation of functional Aryl Mesylates and Chlorides; Hiyama Coupling of Aryl Mesylates; Direct Arylation of Heterocycles with Aryl Mesylates; Borylation of Aryl Mesylates.

2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole (CM-Phos) is an organic compound with catalytic activity. 2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole can be used as an efficient catalyst for cross-coupling reactions of various alcohols and olefins. 2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole shows important application potential in pharmaceutical and material science.

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

2-(2-DicyclohexylphosphaNYL-phenyl)-1-methyl-1H-indole can be prepared in one step from N-methyl-2-phenyl-3-bromoindole with chlorodicyclohexylphosphine.