1-Methyl-2-phenylindole

WHITE TO LIGHT GREEN-TAN CRYSTALS OR CRYST. POWDER

Reactant for preparation of:

• Cyano indoles
• Difluorohydroxy indoles

Reactant for:

• Carboxylation of indoles
• Allylation of indoles
• Formylation of indoles
• Nitrosylation of indoles

Tetrahedron Letters, 34, p. 2059, 1993 DOI: 10.1016/S0040-4039(00)60345-3

Reaction of 1-methyl-2-phenylindole with nitrogen dioxide or with nitrous acid (NaNO₂-CH₃COOH) in benzene has been studied. 1-Methyl-2-phenylindole is reported to react with malondialdehyde (MDA) and 4-hydroxyalkenals to afford a stable chromophore with intense maximal absorbance at 586nm.

[1] Jason W. Johnston. “Evaluation of the 1-methyl-2-phenylindole colorimetric assay for aldehydic lipid peroxidation products in plants: Malondialdehyde and 4-hydroxynonenal.” Plant Physiology and Biochemistry 45 2 (2007): Pages 108-112.
[2] Dominique Gérard-Monnier. “Reactions of 1-Methyl-2-phenylindole with Malondialdehyde and 4-Hydroxyalkenals. Analytical Applications to a Colorimetric Assay of Lipid Peroxidation.” Chemical Research in Toxicology 11 10 (1998): 1176–1183.