1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 性质
| 沸点 | 618.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.142±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO：50 mg/mL（108.55 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 5.99±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 用途与合成方法
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N-Type Ca 2+ Channel 0.11 μM (IC 50 ) |
L-type calcium channel 12.2 μM (IC 50 ) |
NP118809 is a potent N-type calcium channel blocker, with an IC 50 of 0.11 μM; also inhibits L-type calcium channel with an IC 50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC 50 of 7.4 μM.
NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 | 41332-24-5 | 100mg | 744 |
| 2024-11-08 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 | 41332-24-5 | 10mM * 1mLin DMSO | 818 |
