新补骨脂异黄酮
新补骨脂异黄酮 性质
| 熔点 | 195-196℃ |
|---|---|
| 沸点 | 545.0±50.0 °C(Predicted) |
| 密度 | 1.279 |
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | DMF：20mg/mL； DMF:PBS (pH 7.2) (1:4)：0.1 mg/mL；二甲基亚砜：10mg/mL；乙醇：1mg/mL |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 6.92±0.20(Predicted) |
| 颜色 | 白色至浅黄色至浅橙色 |
| 最大波长(λmax) | 300nm(lit.) |
| 主要应用 | 食品和饮料 |
| InChI | 1S/C20H18O4/c1-12(2)3-4-14-9-13(5-8-18(14)22)17-11-24-19-10-15(21)6-7-16(19)20(17)23/h3,5-11,21-22H,4H2,1-2H3 |
| InChIKey | OBGPEBYHGIUFBN-UHFFFAOYSA-N |
| SMILES | OC1=CC=C(C(C(C2=CC(CC=C(C)C)=C(O)C=C2)=CO3)=O)C3=C1 |
新补骨脂异黄酮 用途与合成方法
DNA polymerase
Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED
50
=25 μM) and cytokine (ED
50
s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages.
Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED
50
of 19.94 μM in activated RAW264.7 cells.
Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells.
Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner.
Neobavaisoflavone (2-8 μM; 7 d) inhibits RANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage.
Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice.
| Animal Model: | C57BL/6 female mice (8 weeksd; 20-25 g) were removed bilateral ovaries |
| Dosage: | 30 mg/kg |
| Administration: | I.p. for 6 weeks |
| Result: | Attenuated bone loss by inhibiting osteoclast activation and promoting osteogenesis in ovariectomized mice. |
新补骨脂异黄酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-06 | N1122 | 新补骨脂异黄酮 | 41060-15-5 | 5mg | 80 |
| 2026-06-06 | N1122 | 新补骨脂异黄酮 | 41060-15-5 | 25mg | 340 |
