Ruthenium Red is an inhibitor of ryanodine receptor (RyR) channels (1). It is also an inhibitor of mitochondrial ETC complexes I and III (2). Dyes and metabolites.
Ruthenium Red acts as an inhibitor of mitochondrial ETC complexes I and III. Inhibitor of mitochondrial calcium uniporter
Blocks Ca 2+ uptake and release from mitochondria, and Ca 2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC 50 = 14 nM) and voltage-sensitive Ca 2+ channels to inhibit neurotransmitter release.
