BENZYLHYDRAZINE DIHYDROCHLORIDE

slightly yellow to beige powder

Benzylhydrazine dihydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Poison by intraperitoneal route.Questionable carcinogen with experimental neoplastigenicdata. When heated to decomposition it emits very toxicfumes of HCl and NOx.

Step 1: Tert-butyl hydrazinecarboxylate was reacted in acetone with MgSO4 and HOAc. The mixture was heated to reflux. After cooling and filtration, concentration gave a white solid (1).
Step 2: Compound (1) was dissolved in toluene with solid KOH and a phase-transfer catalyst. Benzyl bromide was added at 50??C. The temperature was then raised to 80??C. After completion, the mixture was washed, dried, and concentrated to give an oil (2f).
Step 3: 2N HCl was added to a THF solution of (2f). The mixture was heated at reflux. After concentration and drying, the dihydrochloride salt (3f) was obtained by filtration.