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noxytiolin

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noxytiolin Basic information
noxytiolin Chemical Properties
  • Melting point:88-90°
  • Boiling point:203.7±42.0 °C(Predicted)
  • Density 1.223±0.06 g/cm3(Predicted)
  • pka13.45±0.10(Predicted)
Safety Information
  • ToxicityLD50 orally in mice: >3 g/kg (Aebi, Hafstetter)
noxytiolin Usage And Synthesis
  • OriginatorNoxyflex,Geistlich,UK,1964
  • Manufacturing Process400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.
  • Therapeutic FunctionAntifungal
noxytiolin (15599-39-0)Related Product Information
noxytiolin SupplierMore
  • Company Name:Hubei Baidu Chemical Co., Ltd
  • Tel:13627137652 027-59223020-
  • Email:1438180055@qq.com;1438580055@qq.com
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