Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).
ChEBI: Treosulfan is a methanesulfonate ester.
Odorless white crystalline powder.
Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .
Flash point data for treosulfan are not available; however, treosulfan is probably combustible.
Treosulfan is a biofunctional alkylating agent.', 'Treosulfan is bifunctional alkylating agent.', 'Treosulfan/l-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan; NSC 39069. It is a prodrug of a bifunctional alkylating cytotoxic agent. Treosulfan can be activated non-enzymatically to two active epoxides. It is used to tre at ovarian cancer.
Alkylating agent for ovarian cancer
Confirmed carcinogen.
Poison by intravenous route. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of SOx.
Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.
