Uses
Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).
Definition
ChEBI: Treosulfan is a methanesulfonate ester.
General Description
Odorless white crystalline powder.
Air & Water Reactions
Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .
Fire Hazard
Flash point data for treosulfan are not available; however, treosulfan is probably combustible.
Clinical Use
Alkylating agent for ovarian cancer
Safety Profile
Confirmed carcinogen.
Poison by intravenous route. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of SOx.
Metabolism
Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.
