299-75-2

Name	treosulfan
CAS	299-75-2
EINECS(EC#)	206-081-0
Molecular Formula	C6H14O8S2
MDL Number	MFCD02258964
Molecular Weight	278.301
MOL File	299-75-2.mol

Chemical Properties

Melting point	76-78 °C
Boiling point	359.3°C (rough estimate)
density	1.305 (estimate)
refractive index	1.5630 (estimate)
storage temp.	Store at -20°C
solubility	Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	12.36±0.20(Predicted)
color	Off-White to Pale Beige
optical activity	[α]/D -4.9 to -5.9°, c =1 in acetone
Water Solubility	H2O: 5mg/mL, clear
CAS DataBase Reference	299-75-2
IARC	1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System	Treosulfan (299-75-2)

Safety Data

RIDADR	2811
HazardClass	6.1(b)
PackingGroup	III
Safety Profile	Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. less more
Hazardous Substances Data	299-75-2(Hazardous Substances Data)
Toxicity	LDLo intravenous in dog: 222mg/kg less more

Hazard Information

General Description

Odorless white crystalline powder.

Air & Water Reactions

Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .

Fire Hazard

Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Uses

Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).

Definition

ChEBI: Treosulfan is a methanesulfonate ester.

Biological Activity

Treosulfan is a biofunctional alkylating agent.''Treosulfan is bifunctional alkylating agent.''Treosulfan/l-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan; NSC 39069. It is a prodrug of a bifunctional alkylating cytotoxic agent. Treosulfan can be activated non-enzymatically to two active epoxides. It is used to tre at ovarian cancer.

Clinical Use

Alkylating agent for ovarian cancer

Drug interactions

Potentially hazardous interactions with other drugs
None known

Metabolism

Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.

storage

Store at -20°C

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