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55-98-1

Name Busulfan
CAS 55-98-1
EINECS(EC#) 200-250-2
Molecular Formula C6H14O6S2
MDL Number MFCD00007562
Molecular Weight 246.3
MOL File 55-98-1.mol

Chemical Properties

Appearance White Crystalline Solid
Melting point  114-117 °C(lit.)
Boiling point  359.3°C (rough estimate)
density  1.305 (estimate)
refractive index  1.5630 (estimate)
Fp  9℃
storage temp.  Inert atmosphere,Room Temperature
solubility  Very slightly soluble in water, freely soluble in acetone and in acetonitrile, very slightly soluble in ethanol (96 per cent).
form  Crystalline Powder
color  Pale Brown
Water Solubility  Decomposes
Usage Alkylating agent with antileukemic activity. Antineoplastic
Merck  1505
BRN  1791786
Stability: Moisture Sensitive
CAS DataBase Reference 55-98-1(CAS DataBase Reference)
IARC 1 (Vol. 4, Sup 7, 100A) 2012
EPA Substance Registry System 55-98-1(EPA Substance)

Safety Data

Hazard Codes  T+,T
Risk Statements 
R45:May cause cancer.
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R63:Possible risk of harm to the unborn child.
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  EK1750000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29053990
Safety Profile
Confirmed carcinogen producing leukemia, kidney, and uterine tumors. Experimental neoplastigenic and tumorigenic data. Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and possibly other routes. Ingestion by pregnant women can cause cancer of the reproductive system of the fetus includtng the uterus. Human teratogenic effects by ingestion and possibly other routes include developmental abnormaltties of the eye, ear, craniofacial area including the nose and tongue, gastrointestinal system, endocrine system, urogenital system, and other unspecified areas. Other human reproductive effects by ingestion and possibly other routes include: impotence, changes in the uterus, cervix, and vagina, and menstrual-cycle dtsorders. Experimental reproductive effects. Human systemic effects by ingestion: general arteriolar or venous ddation of the eye, changes in structure or function of salivary glands. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES.
Hazardous Substances Data 55-98-1(Hazardous Substances Data)
Toxicity
LD50 i.v. in rats: 1.8 mg/kg (Scherf)

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