ChemicalBook CAS DataBase List 6055-19-2

6055-19-2

Name	Cyclophosphamide monohydrate
CAS	6055-19-2
EINECS(EC#)	200-015-4
Molecular Formula	C7H17Cl2N2O3P
MDL Number	MFCD00149395
Molecular Weight	279.1
MOL File	6055-19-2.mol

Synonyms

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane 2-oxide bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate CPA CYCLOPHOSPHAMIDE CYCLOPHOSPHAMIDE HYDRATE CYCLOPHOSPHAMIDE MONOHYDRATE CYCLOPHOSPHAMID MONOHYDRATE CYTOXAN ENDOXON N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate TIMTEC-BB SBB003026 (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra

Chemical Properties

Appearance	White to Off-White Solid
Melting point	49-51 °C (lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	Crystals or Crystalline Powder
color	White to almost white
Water Solubility	40 g/L
Usage	It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. Th
Merck	14,2747
BRN	8167897
Stability:	Hygroscopic
Major Application	forensics and toxicology veterinary
InChI	InChI=1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChIKey	PWOQRKCAHTVFLB-UHFFFAOYSA-N
SMILES	P1(=O)(OCCCN1)N(CCCl)CCCl.O
CAS DataBase Reference	6055-19-2(CAS DataBase Reference)
IARC	1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System	6055-19-2(EPA Substance)

Safety Data

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H340-H350-H360FD
Precautionary statements	P202-P264-P270-P280-P301+P310-P405
Hazard Codes	T
Risk Statements	R45:May cause cancer. R25:Toxic if swallowed. R61:May cause harm to the unborn child. R36/37/38:Irritating to eyes, respiratory system and skin . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S53:Avoid exposure-obtain special instruction before use . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S37/39:Wear suitable gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
RIDADR	UN 3464 6.1/PG 3
WGK Germany	3
RTECS	RP6157750
F	10
HazardClass	6.1
PackingGroup	II
HS Code	29349990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Carc. 1B Muta. 1B Repr. 1A
Safety Profile	Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx. less more

Raw materials And Preparation Products

Hazard Information

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. CYCLOPHOSPHAMIDE MONOHYDRATE reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. CYCLOPHOSPHAMIDE MONOHYDRATE(6055-19-2) undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Fire Hazard

This chemical is probably combustible.

Chemical Properties

White to Off-White Solid

Uses

alkylating agent in cancer therapy

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

antineoplastic, alkylating agent

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Definition

ChEBI: The monohydrate of cyclophosphamide.

Brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Nanjing Daqin Pharmaceutical Technology Co., Ltd.

Telephone025-025-58470199 18351831988

Websitehttp://www.daqinpharma.cn

Shanghai Boyle Chemical Co., Ltd.

Telephone 021-50182298 021-50180596

Websitehttp://www.boylechem.com

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

future industrial shanghai co., ltd

Telephone400-0066400 13621662912

Websitehttp://www.jonln.com

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

Alfa Aesar

Telephone400-6106006

Websitehttp://chemicals.thermofisher.cn

TCI (Shanghai) Development Co., Ltd.

Telephone021-67121386

Websitehttps://www.tcichemicals.com/CN/zh/

Beijing HwrkChemical Technology Co., Ltd

Telephone89508211 18501085097

Websitehttp://www.hwrkchemical.com

Energy Chemical

Telephone 400-0056266

Websitehttp://www.energy-chemical.com

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone15527621225; 15527621225

Websitehttp://www.farchem.com/

Shandong Xiya Chemical Co., Ltd

Telephone13355009207 13355009207

Websitehttp://www.xiyashiji.com

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

Tianjin heowns Biochemical Technology Co., Ltd.

Telephone400 638 7771

Websitehttp://www.heowns.com

Sinopharm Chemical Reagent Co,Ltd.

Telephone86-21-63210123

Websitehttp://www.reagent.com.cn

1of4

Related Products

Send Inquriy