ChemicalBook CAS DataBase List 6055-19-2

6055-19-2

Name	Cyclophosphamide monohydrate
CAS	6055-19-2
EINECS(EC#)	200-015-4
Molecular Formula	C7H17Cl2N2O3P
MDL Number	MFCD00149395
Molecular Weight	279.1
MOL File	6055-19-2.mol

Synonyms

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE HYDRATE 2-[BIS(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane 2-oxide bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate CPA CYCLOPHOSPHAMIDE CYCLOPHOSPHAMIDE HYDRATE CYCLOPHOSPHAMIDE MONOHYDRATE CYCLOPHOSPHAMID MONOHYDRATE CYTOXAN ENDOXON N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE-2-OXIDE MONOHYDRATE n,n-bis(beta-chloroethyl)-n',o-propylenephosphoric acid ester amide monohydrate TIMTEC-BB SBB003026 (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr 2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra

Chemical Properties

Appearance	White to Off-White Solid
Melting point	49-51 °C (lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	Crystals or Crystalline Powder
color	White to almost white
Water Solubility	40 g/L
Usage	It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. Th
Merck	14,2747
BRN	8167897
InChIKey	PWOQRKCAHTVFLB-UHFFFAOYSA-N
CAS DataBase Reference	6055-19-2(CAS DataBase Reference)
IARC	1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System	6055-19-2(EPA Substance)

Safety Data

Hazard Codes	T
Risk Statements	R45:May cause cancer. R25:Toxic if swallowed. R61:May cause harm to the unborn child. R36/37/38:Irritating to eyes, respiratory system and skin . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S53:Avoid exposure-obtain special instruction before use . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S37/39:Wear suitable gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
RIDADR	UN 3464 6.1/PG 3
WGK Germany	3
RTECS	RP6157750
F	10
HazardClass	6.1
PackingGroup	II
HS Code	29349990
Safety Profile	Confirmed human carcinogen. Poison by ingestion and intravenous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-, PO,, and NOx. less more

Raw materials And Preparation Products

Hazard Information

General Description

Fine white crystalline powder with a slightly bitter taste. Little or no odor.

Reactivity Profile

Polymerization can occur at temperatures > 120° F. CYCLOPHOSPHAMIDE MONOHYDRATE reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.

Air & Water Reactions

Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. CYCLOPHOSPHAMIDE MONOHYDRATE(6055-19-2) undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.

Fire Hazard

This chemical is probably combustible.

Chemical Properties

White to Off-White Solid

Uses

alkylating agent in cancer therapy

Uses

An immunosuppressive, cytotoxic apoptosis inducer.

Uses

antineoplastic, alkylating agent

Uses

It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.

Definition

ChEBI: The monohydrate of cyclophosphamide.

Brand name

Cytoxan (Bristol-Myers Squibb); Neosar (Sicor).

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Material Safety Data Sheet(MSDS)

Spectrum Detail

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