NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1].
NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor with IC50 of 1.8 and 3.6 μM, respectively. It can be used for the study of mammalian circadian rhythms.
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.
| Animal Model: | Adult C57BL/6J background male mice (8 weeks old) |
| Dosage: | 5 , 15 mM |
| Administration: | Infused into the lateral ventricle, constant dark condition |
| Result: | Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM. | < /tr>
| CKIα 1.8 μM (IC 50 ) | CKIδ 3.6 μM (IC 50 ) |
CKIα: 1.8 μM (IC50); CKIδ: 3.6 μM (IC50)
[1] Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998. DOI:
10.1021/acs.jmedchem.8b01541
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