Uses
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1].
Biological Activity
NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor with IC50 of 1.8 and 3.6 μM, respectively. It can be used for the study of mammalian circadian rhythms.
in vivo
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.
| Animal Model: | Adult C57BL/6J background male mice (8 weeks old) |
| Dosage: | 5 , 15 mM |
| Administration: | Infused into the lateral ventricle, constant dark condition |
| Result: | Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM. | < /tr>
target
| CKIα 1.8 μM (IC 50 ) | CKIδ 3.6 μM (IC 50 ) |
IC 50
CKIα: 1.8 μM (IC
50); CKIδ: 3.6 μM (IC
50)
References
[1] Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998. DOI:
10.1021/acs.jmedchem.8b01541
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