1,2,3,4-Tetrahydro-quinoline-6-carboxylic acid methyl ester

38896-30-9

177478-49-8

The general procedure for the synthesis of methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate from methyl 6-quinolinecarboxylate was as follows: carbon-loaded palladium (1.50 g, 10% mass fraction) and ammonium formate (10.5 g, 165 mmol) were added in methanol (20 mL), followed by methyl 6-quinolinecarboxylate (1.20 g, 6.41 mmol). The reaction mixture was stirred at 70°C for 2 hours. Upon completion of the reaction, the synthesis was processed according to the synthesis method of Step 1 of Example 2 to afford the white solid product methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate (1.20 g) in 97.9% yield.