化合物 YM-254890
化合物 YM-254890 性质
| 沸点 | 1232.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 溶于DMSO（高达10mg/ml） |
| 形态 | 冻干固体 |
| 酸度系数(pKa) | 12.52±0.70(Predicted) |
| 颜色 | 白色或灰白色 |
| 稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
化合物 YM-254890 用途与合成方法
G αq/11 protein
YM-254890 inhibits platelet aggregation induced by ADP (2, 5 and 20 μM) in human platelet-rich plasma with IC 50 values of 0.37, 0.39 and 0.51 μM. ADP mediates platelet aggregation via two G protein-coupled receptors, P2Y 1 and P2Y 12 . The effect of YM-254890 on the P2Y 1 and P2Y 12 signal transduction pathways using C6-15 cells stably expressing the human P2Y 1 or P2Y 12 receptors is examined. Stimulation of P2Y 1 -C6-15 cells by 2MeSADP leads to increases in intracellular calcium mobilization. In this assay, YM-254890 inhibits the increase in [Ca 2+ ] i with an IC 50 value of 0.031 μM. In contrast, 2MeSADP-induced inhibition of forskolin-stimulated adenylyl cyclase activity in P2Y 12 -C6-15 cells is unaffected by YM-254890 at 40 μM.
化合物 YM-254890 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-111557 | 化合物 YM-254890 | 568580-02-9 | 250 μg | 3000 |
| 2026-09-15 | HY-111557 | 化合物 YM-254890 | 568580-02-9 | 500 μg | 4800 |
