Cloxacillin benzathine

Cloxacillin benzathine is a valuable half-synthesized antibiotic used in veterinary medicine to treat infections caused by Gram positive and Gram negative bacteria. Given its high bioactivity, this compound is generally used to prevent infection and treat bovine mastitis, one of the most common diseases in dairy animals. This chemical compound was usually crystallized by precipitation from solutions after the reaction of two raw materials. The SEM photos indicate that the products are general needle-like crystals with some aggregates among them[1-2].

Antibacterial.

Cloxacillin Benzathine is a salt of Cloxacillin is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.

[1] J. Li, J. Wang, Y. Bao. “Effects of Sonocrystallization on the Crystal Size Distribution of Cloxacillin Benzathine Crystals.” Chemical Engineering Technology 36 8 (2013): 1341–1346.
[2] R. S. Araújo. “Cloxacillin benzathine-loaded polymeric nanocapsules: Physicochemical characterization, cell uptake, and intramammary antimicrobial effect.” Materials science engineering. C, Materials for biological applications 134 1 (2019): 110006.