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Cloxacillin-13C4 SodiuM Salt

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Cloxacillin-13C4 SodiuM Salt Basic information
Cloxacillin-13C4 SodiuM Salt Chemical Properties
  • Melting point:170°C
  • storage temp. 2-8°C
  • solubility H2O: 50 mg/mL, clear, colorless
  • Water Solubility Soluble in water
  • Stability:Stable. Incompatible with strong oxidizing agents. Refrigerate.
  • CAS DataBase Reference642-78-4(CAS DataBase Reference)
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MSDS
Cloxacillin-13C4 SodiuM Salt Usage And Synthesis
  • Chemical PropertiesWhite Crystalline Powder
  • OriginatorOrbenin,Beecham,UK,1962
  • UsesCloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.
  • UsesCloxacillin-13C4 SodiuM Salt, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lac tamase due to its inhibitory effects on beta-lactamase binding.
  • UsesLabelled S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.
  • UsesRopivacaine (R675000) metabolite.
  • Manufacturing ProcessThe reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5- methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-ochlorophenyl-5-methyl-4-isoxazolylpenicillin (9.98 g) as a pale yellow solid. Colorimetric assay with hydroxylamine against a benzylpenicillin standard indicated a purity of 68%.
    The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid chloride was prepared, was obtained by hydrolysis of the ester product of the reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in methanolic sodium methoxide. Reaction with thionyl chloride gave the starting material.
  • brand nameCloxapen (GlaxoSmithKline); Tegopen (Apothecon).
  • Therapeutic FunctionAntibacterial
  • Purification MethodsPurify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}
Cloxacillin-13C4 SodiuM Salt Preparation Products And Raw materials
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