ANGIOTENSIN III, HUMAN

Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT₁) and AT₂ receptors, with a 30-fold higher affinity for AT₂ compared with AT₁ in HEK293 cells. Ang III is the preferred agonist for renal AT₂ receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.

ChEBI: Angiotensin III is a peptide.

AT2 Receptor

[1] Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. DOI:10.1042/CS20110036
[2] Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. DOI:10.1161/HYPERTENSIONAHA.112.191403
[3] Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. DOI:10.1042/CS20130396