Description
Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT
1) and AT
2 receptors, with a 30-fold higher affinity for AT
2 compared with AT
1 in HEK293 cells. Ang III is the preferred agonist for renal AT
2 receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity
in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.
