IN 1130 is a novel transforming growth factor-?β type I receptor kinase (ALK5) inhibtior. In one study, it showed that IN-1130 was effective in prevention and treatment of renal fibrosis in rat unilateral ureteral obstruction model.
IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC50 of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models.
