基本属性 生物活性靶点体外研究体内研究 用途与合成方法 曲札芪苷 价格(试剂级) 供应商 供应信息 相关产品
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曲札芪苷

曲札芪苷

中文名称:曲札芪苷
英文名称:Piceatannol 3'-O-glucoside
CAS号:94356-26-0
分子式:C20H22O9
分子量:406.38
EINECS号:
Mol文件:94356-26-0.mol
曲札芪苷 结构式

曲札芪苷 性质

熔点 >219°C (dec.)
沸点 721.6±60.0 °C(Predicted)
密度 1.593±0.06 g/cm3(Predicted)
储存条件 Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度 DMSO(轻微)、乙醇(轻微、超声处理)、甲醇(轻微)
酸度系数(pKa) 9.16±0.10(Predicted)
形态 固体
颜色 白色至类白色

曲札芪苷 用途与合成方法

Piceatannol 3'-O-glucoside 是 Rhubarb 的一种活性成分,通过抑制精氨酸酶 (Arginase) 活性激活内皮细胞一氧化氮合酶 (NO synthase),抑制 Arginase I 和 Arginase II,IC50 值分别为 11.22 μM 和 11.06 μM。

NO synthase
IC50: 11.22 μM (Arginase I), 11.06 μM (Arginase II)

Piceatannol 3'-O-glucoside (Piceatannol-3'-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3'-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3'-O-glucoside significantly decreases arginase I activity (75±5% at 1 µM, 72±7% at 3 µM, 62±1% at 10 µM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 µM Piceatannol 3'-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3'-O-glucoside (from 0 to 120 µM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 µM for the liver lysate and 11.06 µM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3'-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3'-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 µM and IC 50 value is 69 µM.

In order to ascertain whether Piceatannol 3'-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3'-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3'-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3'-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD.

曲札芪苷 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-N2237 曲札芪苷 94356-26-0 1mg 800
2024-11-08 HY-N2237 曲札芪苷 5 mg 2150

曲札芪苷供应商 更多

成都普菲德对照品科技有限公司
黄金产品
联系电话:028-82610909 15882229804
产品介绍:
中文名称:曲札茋苷
英文名称:3,5,3',4'-trihydroxy-stilbene -3'-b-D-glucoside
CAS:94356-26-0
纯度:HPLC98%
包装信息:20mg/1200
备注:仅供实验室对照及药理研究使用,不能作为其他用途
成都昂赛思生物科技有限公司
黄金产品 大货 现货
联系电话: 13518187787
产品介绍:
中文名称:曲札芪苷;白皮杉醇-3'-O-葡萄糖苷
英文名称:Piceatannol-3'-O-glucoside
CAS:94356-26-0
纯度:>98%
包装信息:20mg;100mg;500mg
备注:G级|
库存量:10g
现货日期:2024/12/16 16:16:40
成都普思生物科技股份有限公司
黄金产品
联系电话:028-85370565-229 18080489829
产品介绍:
中文名称:白皮杉醇-3'-O-葡萄糖苷
英文名称:Piceatannol 3'-O-glucoside
CAS:94356-26-0
纯度:98.0%(HPLC)
包装信息:10mg
备注:现货供应,当天发货
上海莫奇生物科技有限公司
现货
联系电话:021-38218169 13341702378
产品介绍:
中文名称:曲札茋苷;白皮杉醇-3-O-葡萄糖苷
英文名称:Piceatannol3-O-glucoside
CAS:94356-26-0
纯度:HPLC>=98%
包装信息:20mg;100mg;1g
备注:量大优惠,用于医药研究 。
库存量:1g
现货日期:2024/12/19 21:20:32
云南西力生物技术股份有限公司
联系电话:0871-65217109 13211707573;
产品介绍:
中文名称:白皮杉醇 3'-O-葡萄糖苷
英文名称:Piceatannol 3'-O-glucoside
CAS:94356-26-0
纯度:98.5%
包装信息:5mg
备注:BBP03406

最新发布供应信息

白皮杉醇 3'-O-葡萄糖苷|T3S0401|TargetMol
TargetMol中国(陶术生物) 2024-12-12

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