曲札芪苷
- CAS号:94356-26-0
- 英文名:Piceatannol 3'-O-glucoside
- 中文名:曲札芪苷
- CBNumber:CB12681279
- 分子式:C20H22O9
- 分子量:406.38
- MOL File:94356-26-0.mol
- 熔点 :>219°C (dec.)
- 沸点 :721.6±60.0 °C(Predicted)
- 密度 :1.593±0.06 g/cm3(Predicted)
- 储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
- 溶解度 :DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
- 酸度系数(pKa) :9.16±0.10(Predicted)
- 形态 :Solid
- 颜色 :White to Off-White
曲札芪苷性质、用途与生产工艺
- 生物活性 Piceatannol 3'-O-glucoside 是 Rhubarb 的一种活性成分,通过抑制精氨酸酶 (Arginase) 活性激活内皮细胞一氧化氮合酶 (NO synthase),抑制 Arginase I 和 Arginase II,IC50 值分别为 11.22 μM 和 11.06 μM。
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靶点
NO synthase
IC50: 11.22 μM (Arginase I), 11.06 μM (Arginase II) -
体外研究
Piceatannol 3'-O-glucoside (Piceatannol-3'-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3'-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3'-O-glucoside significantly decreases arginase I activity (75±5% at 1 µM, 72±7% at 3 µM, 62±1% at 10 µM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 µM Piceatannol 3'-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3'-O-glucoside (from 0 to 120 µM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 µM for the liver lysate and 11.06 µM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3'-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3'-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 µM and IC 50 value is 69 µM.
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体内研究
In order to ascertain whether Piceatannol 3'-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3'-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3'-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3'-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD.
- 更新日期:2025/02/08
- 产品编号:HY-N2237
- 产品名称:曲札芪苷 Piceatannol 3'-O-glucoside
- CAS编号:94356-26-0
- 包装:1mg
- 价格:700元
- 更新日期:2025/02/08
- 产品编号:HY-N2237
- 产品名称:曲札芪苷 Piceatannol 3'-O-glucoside
- CAS编号:94356-26-0
- 包装:5 mg
- 价格:1650元
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