1-Hexadecyl lysophosphatidic acid

Product Name1-Hexadecyl lysophosphatidic acid
CAS52603-03-9
MFC19H41O6P
MW396.5
EINECS
MOL File52603-03-9.mol

Chemical Properties

Melting point	66-67 °C(Solvent: Chloroform)
Boiling point	538.584±60.00 °C(Press: 760.00 Torr)(predicted)
Density	1.066±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	Storage temp. -20°C
solubility	DMF: 5 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:1): 0.5 mg/ml
form	A crystalline solid
pka	1.841±0.10(predicted)
color	White to off-white

Usage And Synthesis

Description

1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position.¹ LPA binds to five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.^2,3

Uses

1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility.

Definition

ChEBI: 1-hexadecyl-sn-glycerol 3-phosphate is a 1-alkyl-sn-glycerol 3-phosphate in which the 1-alkyl group is specified as hexadecyl. It is a conjugate acid of a 1-hexadecyl-sn-glycero-3-phosphate(2-).

References

1. Tsukahara, T., Tsukahara, R., Yasuda, S., et al. Different residues mediate recognition of 1-O-oleyl-lysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor γ J. Biol. Chem. 281(6),3398-3407(2006).
2. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions Trends Cell Biol. 4(6),213-219(1994).
3. Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature Pharmacol. Rev. 54,265-269(2002).