WAY 629 is a selective SR-2C agonist. Potent and efficacious 5-HT2C receptor agonists.
Definition
ChEBI: LSM-3233 is a member of carbazoles.
Biological Activity
Selective 5-HT 2C agonist. K i values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT 2C , 5-HT 2A , 5-HT 6 and 5-HT 7 receptors respectively. Stimulates intracellular Ca 2+ mobilization in CHO cells expressing human 5-HT 2C receptors (EC 50 = 72 nM). Reduces food intake in rats.
in vivo
WAY 629 (30 mg/kg; i.p.) decreases feeding behavior in rats[1].
WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains[2].
![1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride Structure](/CAS/GIF/57756-45-3.gif)
