Febrifugine

Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.

It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from Changshan.

Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.

Plasmodium

[1] J. B. KOEPFLI  John A B Jr  J F Mead. AN ALKALOID WITH HIGH ANTIMALARIAL ACTIVITY FROM DICHROA FEBRIFUGA1[J]. Journal of the American Chemical Society, 1947, 69 7: 1837. DOI: 10.1021/ja01199a513
[2] NOEL P. MCLAUGHLIN  Mark P  Paul Evans. The chemistry and biology of febrifugine and halofuginone[J]. Bioorganic & Medicinal Chemistry, 2014, 22 7: Pages 1993-2004. DOI: 10.1016/j.bmc.2014.02.040
[3] KIYOSHI MURATA . Potentiation by febrifugine of host defense in mice against plasmodium berghei NK65[J]. Biochemical pharmacology, 1999, 58 10: Pages 1593-1601. DOI: 10.1016/s0006-2952(99)00244-0