ChemicalBook > Product Catalog > Organic Chemistry > Ethers and derivatives > Ethers, ether-alcohols, ether phenol derivatives > 2-Nitroanisole
2-Nitroanisole Chemical Properties
- Melting point:9-12 °C(lit.)
- Boiling point:273 °C(lit.)
- Density 1.254 g/mL at 25 °C(lit.)
- refractive index n
- Flash point:>230 °F
- solubility alcohol: soluble(lit.)
- Specific Gravity1.254
- Water Solubility 1.45 g/L (20 ºC)
- Merck 14,6584
- BRN 1868032
- Stability:Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference91-23-6(CAS DataBase Reference)
- NIST Chemistry ReferenceBenzene, 1-methoxy-2-nitro-(91-23-6)
- EPA Substance Registry Systemo-Nitroanisole (91-23-6)
2-Nitroanisole Usage And Synthesis
- Chemical Propertiesyellow to amber liquid
- Chemical Properties2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.
- Uses2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
- DefinitionChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
- HazardQuestionable carcinogen.
- Safety ProfileConfirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.
- Potential ExposureA dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.
- Carcinogenicityo-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
- ShippingUN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
- Purification MethodsPurify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
- IncompatibilitiesA strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures ＞110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide ＋ zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
- Waste DisposalUse a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Nitroanisole Preparation Products And Raw materials
- 4-Methyl-2-nitroanisole 1,3-Dinitrobenzene p-Nitrobenzoic acid 2-Methoxyethanol Methoxy Nitrobenzene 3-Nitrobenzaldehyde 3-Nitroanisole 3-Methyl-2-nitroanisole 2-NITROPHENYL CHLOROFORMATE 4-Methoxy-3-nitrobenzoic acid 2,5-Dimethoxy-4-nitroaniline 5-METHOXY-2-METHYL-4-NITROANILINE, TECH., 95 3-METHOXY-2-NITROBENZOIC ACID 3-Methoxy-4-nitrobenzoic acid 3-METHOXY-4-NITROBENZYL ALCOHOL 2'-NITROPHENYL-2-ACETAMIDO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE Sodium 3-nitrobenzenesulphonate