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2-Nitroanisole Basic information
2-Nitroanisole Chemical Properties
  • Melting point:9-12 °C(lit.)
  • Boiling point:273 °C(lit.)
  • Density 1.254 g/mL at 25 °C(lit.)
  • refractive index n20/D 1.561(lit.)
  • Flash point:>230 °F
  • solubility alcohol: soluble(lit.)
  • Specific Gravity1.254
  • Water Solubility 1.45 g/L (20 ºC)
  • Merck 14,6584
  • BRN 1868032
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference91-23-6(CAS DataBase Reference)
  • NIST Chemistry ReferenceBenzene, 1-methoxy-2-nitro-(91-23-6)
  • EPA Substance Registry Systemo-Nitroanisole (91-23-6)
Safety Information
  • Hazard Codes T
  • Risk Statements 45-22
  • Safety Statements 53-45
  • RIDADR UN 2730 6.1/PG 3
  • WGK Germany 3
  • RTECS BZ8790000
  • TSCA Yes
  • HazardClass 6.1
  • PackingGroup III
  • HS Code 29093090
  • Hazardous Substances Data91-23-6(Hazardous Substances Data)
2-Nitroanisole Usage And Synthesis
  • Chemical Propertiesyellow to amber liquid
  • Chemical Properties2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.
  • Uses2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
  • DefinitionChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
  • HazardQuestionable carcinogen.
  • Safety ProfileConfirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.
  • Potential ExposureA dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.
  • Carcinogenicityo-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
  • ShippingUN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
  • Purification MethodsPurify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
  • IncompatibilitiesA strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures >110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide + zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
  • Waste DisposalUse a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Nitroanisole Preparation Products And Raw materials
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